골수 줄기세포와 주사형 MPEG-PCL diblock copolymer를 이용한 조직공학적 골재생
Bone Regeneration with Injectable MPEG-PCL Diblock Copolymer and Bone Marrow Mesenchymal Stem Cell
정유민, 이태형, 박정균, 김원석, 신주희, 이의석, 임재석, 장현석,
소속 상세정보
정유민 ( Jeong You-Min ) - 고려대학교 의과대학 구강악안면외과학교실
이태형 ( Lee Tai-Hyung ) - 고려대학교 의과대학 구강악안면외과학교실
박정균 ( Park Jeong-Kyun ) - 고려대학교 의과대학 구강악안면외과학교실
김원석 ( Kim Won-Suk ) - 고려대학교 의과대학 구강악안면외과학교실
신주희 ( Shin Joo-Hee ) - 고려대학교 의과대학 구강악안면외과학교실
이의석 ( Lee Eui-Seok ) - 고려대학교 의과대학 구강악안면외과학교실
임재석 ( Rim Jae-Suk ) - 고려대학교 의과대학 구강악안면외과학교실
장현석 ( Jang Hyon-Seok ) - 고려대학교 의과대학 구강악안면외과학교실
KMID : 0360120100320010009
Abstract
Aim of the study: As an injectable scaffold, MPEG-PCL diblock copolymer was applied in bone tissue engineering. In vivo bone formation was evaluated by soft X-ray, histology based on the rat calvarial critical size defect model.
Materials and Methods: New bone formation was evaluated with MPEG-PCL diblock copolymer in rat calvarial critical size bone defect. No graft was served as control. 4, 8 weeks after implantation, gross evidence of bone regeneration was evaluated by histology and soft X-ray analysis.
Results: The improved and effective bone regeneration was achieved with the BMP-2 and osteoblasts loaded MPEG-PCL diblock copolymer.
Conclusion: It was confirmed that MPEG-PCL temperature sensitive hydrogels was useful as an injectable scaffold in bone regeneration.
키워드
Injectable scaffold;MPEG-PCL diblock copolymer;Bone tissue engineering;BMP-2; Osteoblasts
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